Madeline is a graduate of the American Musical and Drama Academy in New York, graduating in 2012. She stated on Twitter she currently has a boyfriend and unlike her character, Madeline seems to be "very straight". Apart from acting on camera, she has also acted off broadway in acts such as: Liberty. Madeline also used to do beauty pageants but appears to have stopped.
She is currently starring in Hulu's The Handmaid's Tale as Handmaid Janine, also known as Ofwarren.
- Brewer stated that her favorite scene to film was the withdrawal scene from "Moscow Mule" because she was able to do more specific, extensive research of a drug that has been a large source of struggle for some of her friends.
- The cornrows that her character wore took 20 minutes to apply and were applied every time she came to set.
- She has a septum piercing.
- Samira Wiley is a co-star of hers not only in this series, but also The Handmaid's Tale.