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Rodriguez was born and raised in Manhattan, New York City to Puerto Rican parents. She attended Lehman College in New York.
She is an award-winning member of Labyrinth Theater Compan and best known for her role as Carmen Morales on All My Children (2008–2009). She had a series regular role on the TV series Prime Suspect (2011). She also has recently stared as a main cast member in Fear The Walking Dead as Liza Ortiz (2015). She is also portraying the role of Paz in Starz original series Power.